TRIB2 safeguards naive T cell homeostasis during aging
Summary: Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during aging.Here, we show that TRIB2 is more abundant in naive CD4+ than CD8+ T cells and counteracts resta moisturizer quiescence exit by suppressing AKT activation.TRIB2 deficiency incre